After the Straw Hat Pirates managed to defeat two formidable enemies, Kaido and Big Mom of the Four Emperors, they prepared to set sail for their new destination: Egghead Island. This futuristic island is brimming with advanced technology created by Dr. Vegapunk, a genius scientist working for the World Government. However, chaos ensues when Dr. Vegapunk himself becomes a target of the World Government. Thus begins a new battle for the Straw Hat Pirates, leading them to uncover long-hidden secrets.